Neuroimaging evaluation of high dose methotrexate-induced neurotoxicity in pediatric and young adults: a PET/MRI study
<sup>18</sup>F-FDG PET/MRI revealed short-term increases in brain metabolism post-HDMTX compared with baseline, possibly reflecting neuroinflammation. Long-term follow up scans revealed normalization of brain metabolism or decreased brain metabolism compared to baseline, the latter possibly indicating neurotoxicity.
Authors
- K. Elizabeth Hawk (ORCID: https://orcid.org/0000-0001-5738-2044)
- Yashas Ullas Lokesha (ORCID: https://orcid.org/0000-0002-3397-4309)
- Shashi B. Singh (ORCID: https://orcid.org/0000-0002-5536-0869)
- Sarah Ying Lu-Liang
- Heike Elisabeth Daldrup-Link
- Hyun Su Kim
- Michael Iv
- Tie Liang
- Ricarda von Krüchten
- Lucia Baratto
- Zahra Shokri Varniab
Institutions
- Stanford Medicine (US)
- The Catholic University of Korea Seoul St. Mary's Hospital (KR)
- Catholic University of Korea (KR)
- Stanford University (US)
Publication Details
- Journal
- Frontiers in Neuroimaging
- Published
- 2026-01-13
- DOI
- https://doi.org/10.3389/fnimg.2025.1659480
- Primary Topic
- Acute Lymphoblastic Leukemia research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Cancer Institute