Studying the formation of the zone of calcified cartilage in bovine cartilage explants ex vivo
We present the first <i>ex vivo</i> model allowing to study and modulate cartilage calcification and the formation of the ZCC. We demonstrated an inherent zone-specific calcification pattern within the cartilage explants. This model allows future studies investigating mechanisms of ZCC formation in cartilage repair procedures, and the role of the top layer in pathological cartilage calcifications and potential interventions.
Authors
- A. Schwab (ORCID: https://orcid.org/0000-0002-4576-558X)
- Pieter A.J. Brama (ORCID: https://orcid.org/0000-0003-3405-0551)
- Nicole Kops
- Elias Salzer
- Gerjo J.V.M. van Osch
- Jietao Xu
- Eric Farrell
Institutions
- University College Dublin (IE)
- Erasmus MC (NL)
- Hangzhou Medical College (CN)
- Erasmus University Rotterdam (NL)
- Otto-von-Guericke-Universität Magdeburg (DE)
- Delft University of Technology (NL)
Publication Details
- Journal
- Osteoarthritis and Cartilage Open
- Published
- 2026-01-13
- DOI
- https://doi.org/10.1016/j.ocarto.2026.100743
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00