The aggregate proteome of Caenorhabditis elegans mitochondria implicates shared mechanisms of aging and Alzheimer’s disease
These findings place mitochondrial proteome collapse at the center of aging and AD-seeded pathology, distinguish Aβ- and Tau-driven proteotoxic routes, and nominate a conserved panel of aggregation-prone proteins as mechanistic drivers and candidate biomarkers for early detection and intervention in AD.
Authors
- Akshatha Ganne (ORCID: https://orcid.org/0000-0003-4604-5194)
- Srinivas Ayyadevara (ORCID: https://orcid.org/0000-0002-4572-6361)
- Sonu Pahal (ORCID: https://orcid.org/0000-0001-8332-4198)
- Meenakshisundaram Balasubramaniam (ORCID: https://orcid.org/0000-0003-0273-8757)
- Sue Griffin
- Robert J. Shmookler Reis
Institutions
- University of Arkansas at Little Rock (US)
- Central Arkansas Veterans Healthcare System (US)
- University of Arkansas for Medical Sciences (US)
Publication Details
- Journal
- Frontiers in Aging Neuroscience
- Published
- 2026-01-13
- DOI
- https://doi.org/10.3389/fnagi.2025.1713391
- Primary Topic
- Genetics, Aging, and Longevity in Model Organisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health
- National Institute on Aging