Xiao-Yao-San suppresses psychological distress-related colorectal cancer metastasis and enhances antitumor immune responses through regulating gut microbiota–bile acid axis
XYS prevents psychiatric disorder-associated CRC metastasis and strengthens antitumor immune responses by regulating bsh-expressing gut bacteria and their derived BA profiles. These findings thus offer a novel mechanistic rationale for the potential use of XYS in treating CRC patients with comorbid psychiatric disorders.
Authors
- Zhaozhou Zhang
- Fengjing Jia (ORCID: https://orcid.org/0000-0001-8115-6442)
- Yunfeng Guan
- Xiaojing Zhu (ORCID: https://orcid.org/0009-0002-6478-9998)
- Yuanyuan Feng
- Shiyun Shao
- Yan Wang
- Xiyun Liu
- Xinxin Hou
- Hao Qian
- Wenbin Wu
- Haitao Jiang
- Wang Yao
- Hui Huang
- Ling Zhao
- Jinchao He
- Haidong Guo
- Mingjie Li
Institutions
- Ningbo University (CN)
- Guangzhou University of Chinese Medicine (CN)
- Shanghai Jiao Tong University (CN)
- Ruijin Hospital (CN)
- Shanghai University of Traditional Chinese Medicine (CN)
- Longhua Hospital Shanghai University of Traditional Chinese Medicine (CN)
- Shuguang Hospital (CN)
Publication Details
- Journal
- Phytomedicine
- Published
- 2026-01-13
- DOI
- https://doi.org/10.1016/j.phymed.2026.157820
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00