Exploratory analysis of non-linear clozapine dose-concentration relationship in real-life hospital database
Our data suggest that the non-linear relationship between CLO concentration and its daily dose can be a real-life clinical problem with CLO doses of ∼400 mg/day as the provisional hinge point. Although preliminary, the present results warrant further investigations on non-linear aspects of CLO pharmacology, including "unexpected" CLO concentrations, toxicity, and lack of therapeutic activity.
Authors
- Anna Mach (ORCID: https://orcid.org/0000-0002-2453-5320)
- Przemysław Bieńkowski (ORCID: https://orcid.org/0000-0002-7432-3449)
- Marcin Wojnar (ORCID: https://orcid.org/0000-0001-5138-9050)
- Anna Wnorowska
- Szymon Tyras
- Maria Radziwoń-Zaleska
- Marcin Siwek
Institutions
- Jagiellonian University (PL)
- Medical University of Warsaw (PL)
- University of Michigan (US)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2026-01-13
- DOI
- https://doi.org/10.3389/fphar.2025.1735337
- Primary Topic
- Schizophrenia research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00