Asymmetric adult-onset asthma with periocular xanthogranuloma (AAPOX) associated with IgG4-related disease: a case report

This case further confirms the strong association between AAPOX and IgG4-RD, and represents the first report of asymmetric AAPOX. Surgical excision combined with systemic glucocorticoid therapy proved effective for this condition. Furthermore, the article explores the potential role of IgG4 produced during asthma desensitization therapy in the pathogenesis of IgG4-RD, suggesting that this potential risk should be considered during asthma treatment. This report provides valuable clinical experience for the diagnosis and treatment of such rare diseases.