Investigational insights into the potential of angiotensin type II receptor agonists as therapeutics for idiopathic pulmonary fibrosis

Rapid translation of C21 (now named buloxibutid), the first-in-class orally available AT₂R agonist, to early phase clinical trials for IPF have established its safety and disease-modifying potential. Ongoing development of novel, more highly selective AT₂R agonists may deliver the same clinical benefit as C21 with reduced off-target effects. The AT₂R drug class offers great promise as novel therapeutics, potentially extending beyond IPF to other inflammatory and fibrotic lung diseases.