Protective impact of circulating ω-3 PUFAs on sepsis susceptibility through PCSK9 variant: evidence from Mendelian randomization and animal experiments
In patients with <i>PCSK9</i> mutations, elevated plasma ω-3 PUFAs may reduce susceptibility to sepsis. Therefore, early detection of PUFA levels and PCSK9 genotypes, along with the targeted nutritional supplements, may help reduce sepsis risk in susceptible populations.
Authors
- Simeng He
- Zhengxuan Li
- Qilong Song
- Qi Han
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Qilu Hospital of Shandong University (CN)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2026-01-13
- DOI
- https://doi.org/10.3389/fmed.2025.1701207
- Primary Topic
- Immune Response and Inflammation
- Type
- article
- Field-Weighted Citation Impact
- 0.00