Novel Pyridopyrazine Derivatives as Inverse Agonists of the G Protein-Coupled Receptor 6
This patent highlight describes the development and evaluation of novel pyridopyrazine analogs as potent inverse agonists for G protein-coupled receptor 6 (GPR6). It discloses synthetic methods and pharmacological properties of these new GPR6 modulators.
Authors
- Steven H. Liang (ORCID: https://orcid.org/0000-0003-1413-6315)
- Yinlong Li
Institutions
- Georgia Institute of Technology (US)
- Emory University (US)
- The Wallace H. Coulter Department of Biomedical Engineering (US)
Publication Details
- Journal
- ACS Medicinal Chemistry Letters
- Published
- 2026-01-13
- DOI
- https://doi.org/10.1021/acsmedchemlett.5c00748
- Citations
- 1
- Primary Topic
- Receptor Mechanisms and Signaling
- Type
- article
- Field-Weighted Citation Impact
- 22.24