The olfactory functional network in the Alzheimer’s disease continuum: a resting state fMRI study
Our findings indicate alterations of functional connectivity of the olfactory cortex in subjects with MCI at risk of conversion to AD dementia, even at the early stages of the disease. Additionally, the negative correlation between olfactory ability and the angular gyrus functional connectivity, a cerebral region known to be involved in multisensory integration processing, may be considered as a marker of disease progression.
Authors
- Maria Angela Molinari
- Francesca Benuzzi (ORCID: https://orcid.org/0000-0002-3498-3303)
- Daniela Ballotta (ORCID: https://orcid.org/0000-0003-3039-2589)
- Claudia Casadio (ORCID: https://orcid.org/0009-0000-6295-2240)
- Nicola Filippini (ORCID: https://orcid.org/0000-0003-1513-5269)
- Vanessa Zanelli (ORCID: https://orcid.org/0009-0004-1815-4697)
- Fausta Lui
- Omar Carpentiero
- Manuela Tondelli
- Francesco Ricci
- Annalisa Chiari
Institutions
- University of Modena and Reggio Emilia (IT)
- Azienda Unita' Sanitaria Locale Di Modena (IT)
- Azienda Ospedaliero-Universitaria di Modena (IT)
- IRCCS San Camillo Hospital (IT)
Publication Details
- Journal
- Frontiers in Aging Neuroscience
- Published
- 2026-01-13
- DOI
- https://doi.org/10.3389/fnagi.2025.1744413
- Primary Topic
- Olfactory and Sensory Function Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Università Degli Studi di Modena e Reggio Emila
- National Institutes of Health