Alisol F 24-acetate attenuated metabolic dysfunction-associated steatohepatitis by targeting the KEAP1/NRF2-mediated macrophage pyroptosis
Our findings suggest that ALI suppressed macrophage pyroptosis by targeting KEAP1/NRF2 interactions, providing reliable data on the protective mechanism of natural antioxidants against MASH.
Authors
- Zhiwu Dong
- Weiyi Wu
- Lianxiang Xing
- Keliang Huang
- Wenwei Yang
- Xin Zhang
- Ying Zhang
- Kewen Zhao
Institutions
- Shanghai Second People's Hospital (CN)
- Ministry of Education (TH)
- Shanghai Huangpu District Central Hospital (CN)
Publication Details
- Journal
- Chinese Medicine
- Published
- 2026-01-13
- DOI
- https://doi.org/10.1186/s13020-025-01322-8
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00