Updates in tolerance: future directions to improve kidney allograft survival
Tolerance in kidney transplantation is transitioning from conceptual aspiration to clinical feasibility. Landmark chimerism trials confirm that operational tolerance is possible in selected populations. Future priorities include refining conditioning regimens to reduce toxicity and extending eligibility to higher-risk recipients. Together, these developments suggest that tolerance-based strategies may ultimately transform kidney transplantation from chronic immunosuppression to durable immune re-education.
Authors
- Suthiya Anumas (ORCID: https://orcid.org/0000-0002-2028-5037)
- Adis Tasanarong (ORCID: https://orcid.org/0000-0001-6453-0615)
- Wiwat Chancharoenthana (ORCID: https://orcid.org/0000-0002-2965-146X)
- Thanee Eiamsitrakoon
- E. Tantisattamo
- Pajaree Krisanapan
- Opas Traitanon
Institutions
- Thammasat University (TH)
- American Heart Association (US)
- Mahidol University (TH)
- Pacific Northwest University of Health Sciences (US)
- Thammasat University Hospital (TH)
- Hodges University (US)
- University of California, Irvine Medical Center (US)
- Mahidol Oxford Tropical Medicine Research Unit (TH)
- Ramathibodi Hospital (TH)
- VA Long Beach Healthcare System (US)
- Beaumont Hospital, Troy (US)
Publication Details
- Journal
- Current Opinion in Nephrology & Hypertension
- Published
- 2026-01-12
- DOI
- https://doi.org/10.1097/mnh.0000000000001142
- Primary Topic
- Renal Transplantation Outcomes and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00