Comparison of the effect of DNA aptamers U31, GR20, GR200 and their combination with radiation therapy on the viability of human glioblastoma cells G22 and Sus\fP2

Aptamers have different effects on glioblastoma cell cultures. For Sus\fP2, a combination of radiotherapy with GR20 aptamer is optimal. Either a single application of U31 aptamer or combination of radiotherapy and GR200 aptamer is optimal for G22 cell culture. This result demonstrates the importance of combined therapy and preliminary studies in cell cultures for individualized approach to each CNS tumor.

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Publication Details

Journal
Burdenko s Journal of Neurosurgery
Published
2025-12-30
DOI
https://doi.org/10.17116/neiro2025890625
Primary Topic
Advanced biosensing and bioanalysis techniques
Type
article
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article

Comparison of the effect of DNA aptamers U31, GR20, GR200 and their combination with radiation therapy on the viability of human glioblastoma cells G22 and Sus\fP2

A.V. Ovechkina, D. U. Usachev, Ya. A. Sliman, AV Golanov et al.
Burdenko s Journal of Neurosurgery
Advanced biosensing and bioanalysis techniques
article

Comparison of the effect of DNA aptamers U31, GR20, GR200 and their combination with radiation therapy on the viability of human glioblastoma cells G22 and Sus\fP2

A.V. Ovechkina, D. U. Usachev, Ya. A. Sliman, AV Golanov, G.V. Pavlova, N.A. Antipina, N.S. Samoilenkova, E.A. Savchenko, A.V. Demyanovich, S.A. Pavlova
article en

Abstract

Aptamers have different effects on glioblastoma cell cultures. For Sus\fP2, a combination of radiotherapy with GR20 aptamer is optimal. Either a single application of U31 aptamer or combination of radiotherapy and GR200 aptamer is optimal for G22 cell culture. This result demonstrates the importance of combined therapy and preliminary studies in cell cultures for individualized approach to each CNS tumor.

Burdenko s Journal of NeurosurgeryVol. 89(6)
Moscow Institute of Physics and Technology (RU), Moscow Power Engineering Institute (RU), Sechenov University (RU), Russian Medical Academy of Continuous Professional Education (RU), Botkin Hospital (RU), Burdenko Neurosurgery Institute (RU), Institute of Higher Nervous Activity and Neurophysiology (RU), Moscow Aviation Institute (RU)
Good health and well-being
Openalex Percentile: Top 34%
Advanced biosensing and bioanalysis techniques
DOISourceOpenAlex
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