PARP inhibitor–associated folate deficiency anemia

Following PARPi initiation for BRCA1/2 -related malignancies, at least 3.1% of patients developed marked folate deficiency anemia, precipitating hemoglobin decreases from 11.1 (IQR 9.9-12.1) to 7.0 g/dL (IQR 6.3-7.4) ( P < 0.001), PRBC transfusion dependence (62.5%), and cancer treatment disruptions (75%).

Authors

Institutions

Publication Details

Journal
Blood Red Cells & Iron
Published
2026-01-12
DOI
https://doi.org/10.1016/j.brci.2026.100052
Primary Topic
Folate and B Vitamins Research
Type
article
Field-Weighted Citation Impact
0.00
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

PARP inhibitor–associated folate deficiency anemia

D.I. Nathan, Noa Rippel, Ilan Shapira, P. Klein et al.
Blood Red Cells & Iron
Folate and B Vitamins Research
article

PARP inhibitor–associated folate deficiency anemia

D.I. Nathan, Noa Rippel, Ilan Shapira, P. Klein, J. M. Liu, W. Fu
article en

Abstract

Following PARPi initiation for BRCA1/2 -related malignancies, at least 3.1% of patients developed marked folate deficiency anemia, precipitating hemoglobin decreases from 11.1 (IQR 9.9-12.1) to 7.0 g/dL (IQR 6.3-7.4) ( P < 0.001), PRBC transfusion dependence (62.5%), and cancer treatment disruptions (75%).

Blood Red Cells & IronVol. 2(2)
Icahn School of Medicine at Mount Sinai (US)
Good health and well-being
Openalex Percentile: Top 91%
Folate and B Vitamins Research
DOIOpen Access PDFOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.

PARP inhibitor–associated folate deficiency anemia — D.I. Nathan, Noa Rippel, et al. · Blood Red Cells & Iron (2026) | TGRS Research Map | TGRS