The nuclear receptor ROR-alpha is a critical myogenic regulator of the cardiomyocyte transcriptome, including the alpha-1A adrenergic receptor
Collectively these findings position RORα as a previously unrecognized central regulator of the cardiac myogenic transcriptome and the first recognized transcriptional regulator of <i>Adra1a</i> in cardiomyocytes. Future studies will probe the contribution of RORα-mediated transcriptional regulation of <i>Adra1a</i> to both the response to cardiomyocyte injury and maintenance of circadian biology.
Authors
- Raghu S. Nagalingam (ORCID: https://orcid.org/0000-0003-1095-8303)
- Anton M. Jetten (ORCID: https://orcid.org/0000-0003-0954-4445)
- Britney Alcira
- Wei Huang (ORCID: https://orcid.org/0000-0003-3046-4220)
- Kevin Gerrish (ORCID: https://orcid.org/0000-0002-4236-5329)
- Lacey Boshe (ORCID: https://orcid.org/0000-0002-9848-7499)
- Dhiren Akkina
- Christina Kang
- Hong Soon Kang
- Mansi Goyal
- Amir Aghajanian
- Logan G Kirkland
- Anyue Zhao
- Ju Youn Beak
- Richard L Lutze
Institutions
- University of North Carolina at Chapel Hill (US)
- National Institutes of Health (US)
- National Institute of Environmental Health Sciences (US)
- Virginia Tech (US)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2026-01-12
- DOI
- https://doi.org/10.64898/2026.01.11.698261
- Primary Topic
- Circadian rhythm and melatonin
- Type
- article
- Field-Weighted Citation Impact
- 0.00