Microbiota-driven tryptophan metabolism and AhR triggered intestinal stem cell differentiation: mechanisms of huangqin decoction in ulcerative colitis repair

HQD restores intestinal mucosal integrity and attenuates colonic inflammation by modulating gut microbiota composition, increasing microbial tryptophan metabolites with AhR-agonist activity, activating the AhR signaling pathway, and promoting ISC differentiation into functional epithelial cells. This work reveals a novel "microbiota-tryptophan metabolism-AhR-ISC differentiation" axis underlying HQD's therapeutic efficacy in UC.

Authors

Institutions

Publication Details

Journal
Chinese Medicine
Published
2026-01-13
DOI
https://doi.org/10.1186/s13020-025-01302-y
Primary Topic
Gut microbiota and health
Type
article
Field-Weighted Citation Impact
0.00
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Microbiota-driven tryptophan metabolism and AhR triggered intestinal stem cell differentiation: mechanisms of huangqin decoction in ulcerative colitis repair

Longyun Huang, Jiayang Zeng, Honggang Chi, Shuimei Cen et al.
Chinese Medicine
Gut microbiota and health
article

Microbiota-driven tryptophan metabolism and AhR triggered intestinal stem cell differentiation: mechanisms of huangqin decoction in ulcerative colitis repair

Longyun Huang, Jiayang Zeng, Honggang Chi, Shuimei Cen, Roude Li, Xin Fu, Xiaoxia Liao, Ying Zou, Xiyi Liao
article en

Abstract

HQD restores intestinal mucosal integrity and attenuates colonic inflammation by modulating gut microbiota composition, increasing microbial tryptophan metabolites with AhR-agonist activity, activating the AhR signaling pathway, and promoting ISC differentiation into functional epithelial cells. This work reveals a novel "microbiota-tryptophan metabolism-AhR-ISC differentiation" axis underlying HQD's therapeutic efficacy in UC.

Chinese MedicineVol. 21(1)
Guangdong Medical College (CN), Second Affiliated Hospital of Guangzhou Medical University (CN), Dongguan People’s Hospital (CN), Affiliated Hospital of Guangdong Medical College Hospital (CN), Guangzhou Medical University (CN)
Openalex Percentile: Top 90%
Gut microbiota and health
DOIOpen Access PDFOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.

Microbiota-driven tryptophan metabolism and AhR triggered intestinal stem cell differentiation: mechanisms of huangqin decoction in ulcerative colitis repair — Longyun Huang, Jiayang Zeng, et al. · Chinese Medicine (2026) | TGRS Research Map | TGRS