Expression of PTEN and p53 and Their Clinicopathological Correlation in Breast Cancer

PTEN loss and p53 overexpression were frequent in breast carcinoma and correlated with aggressive tumor features. Combined assessment of these biomarkers may provide prognostic value and support therapeutic decision-making in breast cancer.

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Publication Details

Journal
Cureus
Published
2026-01-12
DOI
https://doi.org/10.7759/cureus.101323
Primary Topic
PI3K/AKT/mTOR signaling in cancer
Type
article
Field-Weighted Citation Impact
0.00
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article

Expression of PTEN and p53 and Their Clinicopathological Correlation in Breast Cancer

Tonushree Purohit, Manasi Dandekar, Soumya Sahu, Deepshikha Verma
Cureus
PI3K/AKT/mTOR signaling in cancer
article

Expression of PTEN and p53 and Their Clinicopathological Correlation in Breast Cancer

Tonushree Purohit, Manasi Dandekar, Soumya Sahu, Deepshikha Verma
article en

Abstract

PTEN loss and p53 overexpression were frequent in breast carcinoma and correlated with aggressive tumor features. Combined assessment of these biomarkers may provide prognostic value and support therapeutic decision-making in breast cancer.

CureusVol. 18(1)
College of Medical Sciences (NP), People’s University (IN), Gandhi Medical College (IN)
Peace, Justice and strong institutions
Openalex Percentile: Top 90%
PI3K/AKT/mTOR signaling in cancer
DOIOpen Access PDFOpenAlex
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Expression of PTEN and p53 and Their Clinicopathological Correlation in Breast Cancer — Tonushree Purohit, Manasi Dandekar, et al. · Cureus (2026) | TGRS Research Map | TGRS