Tricyclazole alleviates Fonsecaea pedrosoi-induced immune suppression of neutrophils by inhibiting DHN-melanin biosynthesis
This study reveals a novel mechanism by which TCZ counteracts <i>F. pedrosoi</i>-mediated suppression of neutrophil antifungal effector functions, particularly oxidative burst and NET formation, thereby facilitating fungal clearance in CBM. These findings provide a novel strategy for CBM treatment by integrating immunomodulation with antifungal therapy.
Authors
- X. P. Liu
- Chunjiao Zheng (ORCID: https://orcid.org/0009-0000-0426-9080)
- Linan Ni
- Yuanyuan Wang (ORCID: https://orcid.org/0000-0002-0467-6070)
- Jingwen Tan (ORCID: https://orcid.org/0000-0002-4965-6911)
- Wei Li
- Qian Yu
- Lianjuan Yang
- Lulu Li
Institutions
- Shanghai Skin Disease Hospital (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2026-01-12
- DOI
- https://doi.org/10.3389/fcimb.2025.1697287
- Primary Topic
- Fungal Infections and Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Second Military Medical University