Hyperammonemia increases the release of pathological extracellular vesicles from monocytes by impairing lysosomal function and autophagy through the TNFα–cAMP–PKA–LC3 pathway
These data unveil that monocytes produce the pathological EV in hyperammonemia and the underlying mechanisms and provide the bases for new treatments to improve cognitive and motor function in hyperammonemia and MHE.
Authors
- María A. Pedrosa (ORCID: https://orcid.org/0000-0001-9553-8513)
- Marta Llansola (ORCID: https://orcid.org/0000-0002-5565-5907)
- Vicente Felipo (ORCID: https://orcid.org/0000-0003-3145-9538)
- Paula Izquierdo-Altarejos
Institutions
- INCLIVA Health Research Institute (ES)
- Centro de Investigacion Principe Felipe (ES)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-01-12
- DOI
- https://doi.org/10.3389/fimmu.2025.1724800
- Primary Topic
- Liver Disease and Transplantation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Generalitat Valenciana
- European Regional Development Fund
- Agencia Estatal de Investigación