Long-term safety and treatment discontinuation patterns of OnabotulinumtoxinA for post-stroke spasticity: a retrospective study
Repeated onabotulinumtoxinA injections were not associated with unexpected safety concerns over long-term follow-up. Approximately 25% of patients discontinued treatment during the observation period, including cases documented as treatment completion due to clinical improvement. Stroke type was associated with treatment discontinuation patterns, supporting the importance of individualized long-term treatment planning.
Authors
- Michiyuki Kawakami (ORCID: https://orcid.org/0000-0001-6459-3325)
- Ken ichi Azuma
- Takayuki Kamimoto (ORCID: https://orcid.org/0000-0002-2135-1809)
- Osamu Oshima (ORCID: https://orcid.org/0000-0003-2689-8181)
- Tetsuya Tsuji
- Naoko Watabe
- Aiko Ishikawa (ORCID: https://orcid.org/0000-0002-9571-7332)
- Yuka Yamada (ORCID: https://orcid.org/0009-0009-7418-0239)
- Ayako Wada
Institutions
- Keio University (JP)
- Keio University Hospital (JP)
Publication Details
- Journal
- BMC Neurology
- Published
- 2026-01-12
- DOI
- https://doi.org/10.1186/s12883-025-04621-7
- Primary Topic
- Botulinum Toxin and Related Neurological Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00