Evaluation of the efficacy and safety of botulinum toxin type A injections for the prevention of aspiration complications in patients with neurogenic dysphagia and posterior sialorrhea of various etiologies

Incorporating salivary gland chemodenervation with incobotulinumtoxinA (100 U) into the diagnostic and treatment algorithm for neurogenic dysphagia and posterior sialorrhea is an effective and safe method for preventing aspiration complications. This technique significantly reduces sialorrhea intensity and the incidence of aspiration pneumonia, improves swallowing function, facilitates patient care, and enhances the rehabilitation prognosis for severe neurological patients, starting from the acute disease phase. Implementing this method into the routine practice of rehabilitation facilities is advisable to reduce mortality, disability, and the financial burden on the healthcare system.

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Publication Details

Journal
S S Korsakov Journal of Neurology and Psychiatry
Published
2025-12-30
DOI
https://doi.org/10.17116/jnevro2025125121126
Primary Topic
Dysphagia Assessment and Management
Type
article
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article

Evaluation of the efficacy and safety of botulinum toxin type A injections for the prevention of aspiration complications in patients with neurogenic dysphagia and posterior sialorrhea of various etiologies

Svetlana Khatkova, A V Knyazev, A.P. Kilina, O.A. Pogoreltseva
S S Korsakov Journal of Neurology and Psychiatry
Dysphagia Assessment and Management
article

Evaluation of the efficacy and safety of botulinum toxin type A injections for the prevention of aspiration complications in patients with neurogenic dysphagia and posterior sialorrhea of various etiologies

Svetlana Khatkova, A V Knyazev, A.P. Kilina, O.A. Pogoreltseva
article en

Abstract

Incorporating salivary gland chemodenervation with incobotulinumtoxinA (100 U) into the diagnostic and treatment algorithm for neurogenic dysphagia and posterior sialorrhea is an effective and safe method for preventing aspiration complications. This technique significantly reduces sialorrhea intensity and the incidence of aspiration pneumonia, improves swallowing function, facilitates patient care, and enhances the rehabilitation prognosis for severe neurological patients, starting from the acute disease phase. Implementing this method into the routine practice of rehabilitation facilities is advisable to reduce mortality, disability, and the financial burden on the healthcare system.

S S Korsakov Journal of Neurology and PsychiatryVol. 125(12)
National Rehabilitation Center (KR), MerLion Pharma (Germany) (DE)
Good health and well-being
Openalex Percentile: Top 21%
Dysphagia Assessment and Management
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Evaluation of the efficacy and safety of botulinum toxin type A injections for the prevention of aspiration complications in patients with neurogenic dysphagia and posterior sialorrhea of various etiologies — Svetlana Khatkova, A V Knyazev, et al. · S S Korsakov Journal of Neurology and Psychiatry (2025) | TGRS Research Map | TGRS