Aberrant Hippo-YAP/TEAD Signaling Drives Malignant Transcriptional Reprogramming in External Auditory Canal Squamous Cell Carcinoma
This study provides evidence for the hyperactivation of YAP/TEAD-driven transcriptional programs in EACSCC, an exceptionally rare malignancy related to chronic tissue damage and inflammation. A comprehensive multiomics approach, including YAP and H3K27Ac ChIP-seq in clinical samples, not only suggested hyperactivation of YAP/TEAD but also identified YAP-PITX2 as a potential oncogenic transcriptional machinery under TEAD-inhibited conditions. Our results may provide a better understanding of EACSCC and contribute to the future development of therapeutic strategies.
Authors
- Muneyuki Masuda (ORCID: https://orcid.org/0000-0002-7479-8356)
- Kensuke Koike (ORCID: https://orcid.org/0000-0003-4428-2348)
- Shinsaku Itoyama
- Takahiro Hongo (ORCID: https://orcid.org/0000-0003-0395-8946)
- Takafumi Nakano (ORCID: https://orcid.org/0000-0003-4298-2041)
- Noritaka Komune (ORCID: https://orcid.org/0000-0002-9521-9878)
- Mayumi Ono (ORCID: https://orcid.org/0000-0001-7649-0323)
- Kenichi Taguchi
- Kuniaki Sato
- Koshi Mimori
- Takashi Nakagawa
- J. Silvio Gutkind
Institutions
- Kyushu University (JP)
- University of California San Diego (US)
- National Hospital Organization Kyushu Cancer Center (JP)
- Kyushu University Beppu Hospital (JP)
Publication Details
- Journal
- Cancer Research Communications
- Published
- 2026-01-12
- DOI
- https://doi.org/10.1158/2767-9764.crc-25-0626
- Primary Topic
- Hippo pathway signaling and YAP/TAZ
- Type
- article
- Field-Weighted Citation Impact
- 0.00