A study of three-time-point dynamic changes in aPS/PT and standard aPL antibodies and their association with IVF pregnancy outcomes in APS-related recurrent pregnancy loss
A post-treatment or early-pregnancy decline in aCL IgG, aPS/PT IgM, or aβ2GPI IgM is associated with successful pregnancy in APS-RPL patients, whereas early-pregnancy elevations in aPS/PT IgM and IgG are strongly linked to pregnancy loss. The distinct dynamic profiles of aPS/PT antibodies underscore their relevance to pregnancy outcomes, highlighting the value of longitudinal aPS/PT monitoring for identifying high-risk patients and informing individualized immunologic management.
Authors
- Fenjian Lu (ORCID: https://orcid.org/0009-0003-3605-2099)
- Panyu Yang (ORCID: https://orcid.org/0009-0009-1945-7741)
- Penghao Li
Institutions
- Chengdu Women's and Children's Central Hospital (CN)
- Third People's Hospital of Chengdu (CN)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2026-01-12
- DOI
- https://doi.org/10.3389/fmed.2025.1738040
- Primary Topic
- Systemic Lupus Erythematosus Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00