Maternal Pregnancy Outcomes and Offspring Risk of Adult-Onset Multiple Sclerosis

In this cohort study, being born LGA and being exposed to maternal diabetes were associated with a higher risk of adult-onset MS, whereas begin born SGA was associated with a lower risk. While high childhood body mass index and diabetes are known MS risk factors, these findings suggest susceptibility may begin as early as the prenatal period.

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Publication Details

Journal
JAMA Neurology
Published
2026-01-12
DOI
https://doi.org/10.1001/jamaneurol.2025.5255
Primary Topic
Multiple Sclerosis Research Studies
Type
article
Field-Weighted Citation Impact
0.00
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article

Maternal Pregnancy Outcomes and Offspring Risk of Adult-Onset Multiple Sclerosis

Katrin Wolfová, Eliza C. Miller, Sarah Tom, Claire S. Riley et al.
JAMA Neurology
Multiple Sclerosis Research Studies
article

Maternal Pregnancy Outcomes and Offspring Risk of Adult-Onset Multiple Sclerosis

Katrin Wolfová, Eliza C. Miller, Sarah Tom, Claire S. Riley, Julie Horn, Bo Lars Engdahl
article en

Abstract

In this cohort study, being born LGA and being exposed to maternal diabetes were associated with a higher risk of adult-onset MS, whereas begin born SGA was associated with a lower risk. While high childhood body mass index and diabetes are known MS risk factors, these findings suggest susceptibility may begin as early as the prenatal period.

JAMA NeurologyVol. 83(2)
Cedars-Sinai Medical Center (US), National Institute of Occupational Health (NO), NewYork–Presbyterian Hospital (US), University of Pittsburgh (US), Norwegian University of Science and Technology (NO), Charles University (CZ), Levanger Hospital (NO), Institute for Family Health (US), Presbyterian Hospital (US), Cedars-Sinai Smidt Heart Institute (US), Columbia University (US)
Good health and well-being
Openalex Percentile: Top 90%
Multiple Sclerosis Research Studies
DOIOpen Access PDFOpenAlex
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Maternal Pregnancy Outcomes and Offspring Risk of Adult-Onset Multiple Sclerosis — Katrin Wolfová, Eliza C. Miller, et al. · JAMA Neurology (2026) | TGRS Research Map | TGRS