Case Report: Prosthetic revision due to aseptic loosening following total knee arthroplasty: a clinical management and pathological mechanism investigation
The integrated protocol effectively treated aseptic loosening. Wear particle-induced chronic synovitis and altered autophagy-related marker expression may be involved in the pathogenesis, providing preliminary clinical and pathological evidence for further research.
Authors
- Tianxiang Yang
- Jun Li (ORCID: https://orcid.org/0000-0001-6383-6065)
- Yinbin Wang (ORCID: https://orcid.org/0000-0003-2535-2531)
- Xueqi Liu
- Jinpeng Liang
- He Shang
- Yumei Ding
- Yi Wang
- Desheng Chen
- Xing He
- Tao Ma
Institutions
- Ningxia Hui Autonomous Region Peoples Hospital (CN)
- Ningxia Medical University (CN)
- Ningxia Medical University General Hospital (CN)
- The Fourth People's Hospital of Ningxia Hui Autonomous Region (CN)
Publication Details
- Journal
- Frontiers in Surgery
- Published
- 2026-01-12
- DOI
- https://doi.org/10.3389/fsurg.2025.1710878
- Primary Topic
- Total Knee Arthroplasty Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China