Metabolic and Orexin-A Responses to Ketogenic Diet and Intermittent Fasting: A 12-Month Randomized Trial in Adults with Obesity
The ketogenic diet was associated with the most pronounced long-term metabolic improvements, whereas 16:8 time-restricted eating yielded faster early responses and the most stable enhancement in Orexin-A levels. These findings indicate distinct metabolic and neuroendocrine adaptation profiles across dietary strategies. Given the small sample size, results should be interpreted cautiously, and larger trials are warranted to clarify the role of Orexin-A as a potential biomarker of dietary response in obesity.
Authors
- Salvatore Allocca
- Marco La Marra (ORCID: https://orcid.org/0000-0001-7488-8493)
- Giovanni Messina (ORCID: https://orcid.org/0000-0002-0011-867X)
- Girolamo Di Maio (ORCID: https://orcid.org/0000-0001-6305-2092)
- Paride Vasco (ORCID: https://orcid.org/0009-0004-6161-7669)
- Fiorenzo MOSCATELLI
- Vincenzo MONDA
- Maria Casillo (ORCID: https://orcid.org/0009-0001-7212-0285)
- Antonietta Monda (ORCID: https://orcid.org/0009-0009-8422-3837)
- Rita Polito (ORCID: https://orcid.org/0000-0003-1313-2574)
- Marcellino Monda
Institutions
- University of Foggia (IT)
- Parthenope University of Naples (IT)
- University of Campania "Luigi Vanvitelli" (IT)
- San Raffaele University of Rome (IT)
- Pegaso University (IT)
- University of Campania "Luigi Vanvitelli" (IT)
Publication Details
- Journal
- Nutrients
- Published
- 2026-01-12
- DOI
- https://doi.org/10.3390/nu18020238
- Primary Topic
- Dietary Effects on Health
- Type
- article
- Field-Weighted Citation Impact
- 0.00