Omaveloxolone promotes functional recovery of spinal cord injury by reducing inflammatory response and regulating macrophage polarization

Our results collectively confirm the efficacy of Omav in repairing spinal cord injury by targeting macrophage polarization and regulating inflammatory responses. This study not only highlights the therapeutic potential of Omav for SCI but also provides a novel pharmacological strategy for SCI treatment.

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Publication Details

Journal
Frontiers in Molecular Neuroscience
Published
2026-01-12
DOI
https://doi.org/10.3389/fnmol.2025.1737798
Primary Topic
Spinal Cord Injury Research
Type
article
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article

Omaveloxolone promotes functional recovery of spinal cord injury by reducing inflammatory response and regulating macrophage polarization

Y. Zhang, Junjin Li, Dunxu Hu, Zhuolin Wu et al.
Frontiers in Molecular Neuroscience
Spinal Cord Injury Research
article

Omaveloxolone promotes functional recovery of spinal cord injury by reducing inflammatory response and regulating macrophage polarization

Y. Zhang, Junjin Li, Dunxu Hu, Zhuolin Wu, Tao Zhang, Pengtian Zhao, Wenchao Dai, Junbo Chen, Erke Gao, Baoyou Fan, Wenlu Yuan, Jiayi Zhang, Zhijian Wei, Dejing Zhang
article en

Abstract

Our results collectively confirm the efficacy of Omav in repairing spinal cord injury by targeting macrophage polarization and regulating inflammatory responses. This study not only highlights the therapeutic potential of Omav for SCI but also provides a novel pharmacological strategy for SCI treatment.

Frontiers in Molecular NeuroscienceVol. 18
Nankai University (CN), Tianjin First Center Hospital (CN), Tianjin Medical University General Hospital (CN), Second Hospital of Shandong University (CN), Shengli Oilfield Central Hospital (CN), Tianjin Hospital (CN), Qilu Hospital of Shandong University (CN), Tianjin Medical University (CN)
Good health and well-being
Openalex Percentile: Top 90%
Spinal Cord Injury Research
DOIOpen Access PDFOpenAlex
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Omaveloxolone promotes functional recovery of spinal cord injury by reducing inflammatory response and regulating macrophage polarization — Y. Zhang, Junjin Li, et al. · Frontiers in Molecular Neuroscience (2026) | TGRS Research Map | TGRS