A comparative analysis of mutational profiles between triple-negative breast cancer and non-triple-negative breast cancer

Our study delineates the distinct genomic mutational landscapes between TNBC and non-TNBC cohorts, and reveals somatic interactions, driver genes, mutational signatures and pathway enrichment. These findings highlight the distinct molecular features of TNBC, which may contribute to its aggressive clinical behavior.

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Publication Details

Journal
Discover Oncology
Published
2026-01-12
DOI
https://doi.org/10.1007/s12672-026-04419-0
Primary Topic
Breast Cancer Treatment Studies
Type
article
Field-Weighted Citation Impact
0.00
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article

A comparative analysis of mutational profiles between triple-negative breast cancer and non-triple-negative breast cancer

Shunheng Zhou, Chenchen Feng, Wanlin Li
Discover Oncology
Breast Cancer Treatment Studies
article

A comparative analysis of mutational profiles between triple-negative breast cancer and non-triple-negative breast cancer

Shunheng Zhou, Chenchen Feng, Wanlin Li
article en

Abstract

Our study delineates the distinct genomic mutational landscapes between TNBC and non-TNBC cohorts, and reveals somatic interactions, driver genes, mutational signatures and pathway enrichment. These findings highlight the distinct molecular features of TNBC, which may contribute to its aggressive clinical behavior.

Discover OncologyVol. 17(1)
University of South China (CN)
Good health and well-being
Openalex Percentile: Top 90%
Breast Cancer Treatment Studies
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A comparative analysis of mutational profiles between triple-negative breast cancer and non-triple-negative breast cancer — Shunheng Zhou, Chenchen Feng, et al. · Discover Oncology (2026) | TGRS Research Map | TGRS