IL-25–ILC2–IL-13 axis improves traumatic brain injury by mediating CXCL-10-dependent regulation of blood brain barrier integrity
IL-25 promotes BBB repair and enhances neurological recovery following TBI by inducing ILC2-derived IL-13, which suppresses CXCL-10 and endothelial pyroptosis. These findings identify IL-25 as a potential therapeutic target for mitigating BBB damage and improving outcomes after TBI.
Authors
- Maosong Zhang
- Zheng Chen (ORCID: https://orcid.org/0000-0001-7129-6644)
- Qifu Wang
- Min Peng
- Xuefei Shao
- Daoxing Shu
- Zhijie Yang
Institutions
- Wannan Medical College (CN)
- First Affiliated Hospital of Wannan Medical College (CN)
Publication Details
- Journal
- Journal of Neuroinflammation
- Published
- 2026-01-12
- DOI
- https://doi.org/10.1186/s12974-026-03696-4
- Primary Topic
- IL-33, ST2, and ILC Pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.00