The role of dopamine release and D2 dopamine receptor in GHRH and somatostatin cells in controlling growth hormone secretion
Dopamine production in GHRH neurons is not necessary for regulating body growth or GH secretion. D2R ablation in GHRH or SST neurons has a small impact on lean mass and GH secretion, indicating that these neurons mediate only a minor part of the effects induced by complete D2R absence in male mice.
Authors
- Alexandre S. Basso (ORCID: https://orcid.org/0000-0002-3302-4792)
- Maria E de Sousa (ORCID: https://orcid.org/0000-0002-8000-3839)
- Daniela O. Gusmão (ORCID: https://orcid.org/0000-0003-3198-4682)
- Junior José Donato
- Marina Galleazzo Martins (ORCID: https://orcid.org/0000-0002-1259-1472)
- Gabriel O. de Souza
Institutions
- Universidade de São Paulo (BR)
- Universidade Brasil (BR)
- Universidade Federal de São Paulo (BR)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2026-01-12
- DOI
- https://doi.org/10.3389/fendo.2025.1741139
- Primary Topic
- Growth Hormone and Insulin-like Growth Factors
- Type
- article
- Field-Weighted Citation Impact
- 0.00