Silver Oxide and Silver Iodide Nanomaterials Through the Green Synthesis from Acacia Senegal Plant and Biocompatibility Their Use as Anti-liver Cancer Agents

Silver iodide (AgI) can be obtained from Acacia Senegal and has the potential to inhibit cancer growth. The present investigation using relevant techniques, can be used for the liver cancer (HePG2) in the cell line treatment with silver oxide (AgO) nano-crystallites. This was achieved by exposing Liver cancer cell (HePG2) and healthy cells (WRL68) to 25,50,100,200, and 400 μg/mL concentrations of AgO. The novelty of the present study is comparison of the two types of cells: the (HePG2) and (WRL68) to the (AgI) from A. Senegal plant, which to our knowledge has not been reported. We also used the IC50 assay, which is a measurement used to describe the effectiveness of a substance in inhibiting or suppressing a specific enzyme or cell activity. The IC50 value represents the concentration of the substance required to inhibit the target biological activity by 50%.the graph in Figure shows an IC50 value of 70 in liver cancer cells, which is a positive result. However, the IC50 value in healthy cells was somewhat low at 193.These are good results because the lower the IC50 value in cancer cells, the better the outcome, and the opposite should be true for healthy cells.