Predictors of achieving clinical remission in ACPA-positive RA-patients treated with abatacept and methotrexate and methotrexate monotherapy: a post-hoc analysis of the AVERT and AVERT-II trials

Determining which patients achieve clinical remission upon methotrexate or abatacept+methotrexate treatment remains challenging. Disease activity at disease presentation and early DAS response were the only consistent predictors for achieving clinical remission. Genetic, imaging and serology parameters did not improve model performance.

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Publication Details

Journal
Seminars in Arthritis and Rheumatism
Published
2026-01-12
DOI
https://doi.org/10.1016/j.semarthrit.2026.152917
Primary Topic
Rheumatoid Arthritis Research and Therapies
Type
article
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article

Predictors of achieving clinical remission in ACPA-positive RA-patients treated with abatacept and methotrexate and methotrexate monotherapy: a post-hoc analysis of the AVERT and AVERT-II trials

S. A. Bergstra, T.W.J. Huizinga, A.H.M. van der Helm van Mil, E. Niemantsverdriet et al.
Seminars in Arthritis and Rheumatism
Rheumatoid Arthritis Research and Therapies
article

Predictors of achieving clinical remission in ACPA-positive RA-patients treated with abatacept and methotrexate and methotrexate monotherapy: a post-hoc analysis of the AVERT and AVERT-II trials

S. A. Bergstra, T.W.J. Huizinga, A.H.M. van der Helm van Mil, E. Niemantsverdriet, M. Verstappen
article en

Abstract

Determining which patients achieve clinical remission upon methotrexate or abatacept+methotrexate treatment remains challenging. Disease activity at disease presentation and early DAS response were the only consistent predictors for achieving clinical remission. Genetic, imaging and serology parameters did not improve model performance.

Seminars in Arthritis and RheumatismVol. 77
Leiden University Medical Center (NL)
Good health and well-being
Openalex Percentile: Top 91%
Rheumatoid Arthritis Research and Therapies
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