Meningovascular neurosyphilis presenting as multifocal stroke in an HIV patient on ART: a diagnostic challenge in a resource-limited setting: case report and literature review

Clinicians should maintain suspicion for meningovascular neurosyphilis in HIV-positive patients presenting with stroke-like deficits regardless of virologic suppression or absence of conventional vascular risk factors. MRI and CSF evaluation are crucial where diagnostic uncertainty persists, and ceftriaxone is an effective alternative when penicillin cannot be accessed. Despite significant neurological recovery, management conclusions cannot be generalized from a single case.

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Publication Details

Journal
AIDS Research and Therapy
Published
2026-01-12
DOI
https://doi.org/10.1186/s12981-026-00844-x
Primary Topic
Syphilis Diagnosis and Treatment
Type
article
Field-Weighted Citation Impact
0.00
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article

Meningovascular neurosyphilis presenting as multifocal stroke in an HIV patient on ART: a diagnostic challenge in a resource-limited setting: case report and literature review

Adamu Tigabu Tessfaw, Matyas Adugna Abebe, Gebeyaw Addis Bezie, Enawgaw Mehari et al.
AIDS Research and Therapy
Syphilis Diagnosis and Treatment
article

Meningovascular neurosyphilis presenting as multifocal stroke in an HIV patient on ART: a diagnostic challenge in a resource-limited setting: case report and literature review

Adamu Tigabu Tessfaw, Matyas Adugna Abebe, Gebeyaw Addis Bezie, Enawgaw Mehari, Dawit Muche Tewabe, Addise Tilahun Fentahun
article en

Abstract

Clinicians should maintain suspicion for meningovascular neurosyphilis in HIV-positive patients presenting with stroke-like deficits regardless of virologic suppression or absence of conventional vascular risk factors. MRI and CSF evaluation are crucial where diagnostic uncertainty persists, and ceftriaxone is an effective alternative when penicillin cannot be accessed. Despite significant neurological recovery, management conclusions cannot be generalized from a single case.

AIDS Research and TherapyVol. 23(1)
Anderson Orthopaedic Clinic (US), Addis Ababa University (ET), Bahir Dar University (ET)
Openalex Percentile: Top 91%
Syphilis Diagnosis and Treatment
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