γ-Mangostin attenuates osteoclastogenesis and bone resorption by suppressing the PI3K/AKT/NF-κB pathway
Our findings demonstrate that γ-Mag inhibits osteoclastogenesis and bone resorption by targeting the PI3K/AKT/NF-κB pathway, thereby blunting the C-FOS/NFATc1 transcriptional program. This study establishes γ-Mag as a promising natural lead compound for the treatment of postmenopausal osteoporosis.
Authors
- Jian Wei (ORCID: https://orcid.org/0000-0002-0431-3472)
- Xiaofeng Feng (ORCID: https://orcid.org/0000-0002-9473-2848)
- Jiayue Xie
- Zhiyang He
Institutions
- Liuzhou General Hospital (CN)
- Fourth Affiliated Hospital of Guangxi Medical University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2026-01-12
- DOI
- https://doi.org/10.3389/fphar.2025.1742401
- Primary Topic
- Natural Compound Pharmacology Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Guangxi Zhuang Autonomous Region
- National Natural Science Foundation of China