Acute gluten-induced inflammatory response highlights CCL20 as a potential biomarker for celiac disease

Gluten reintroduction triggers alterations in the inflammation-related protein profile of patients with CD. CCL20 emerges as a promising diagnostic candidate, its increase in plasma or serum, with low dependence on symptom presentation, may complement existing diagnostic approaches.

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Publication Details

Journal
Frontiers in Immunology
Published
2026-01-12
DOI
https://doi.org/10.3389/fimmu.2025.1745890
Primary Topic
Celiac Disease Research and Management
Type
article
Field-Weighted Citation Impact
0.00

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article

Acute gluten-induced inflammatory response highlights CCL20 as a potential biomarker for celiac disease

Sara Gómez-Aguililla, Beatriz Arau, Carolina Sousa, Concepción Núñez et al.
Frontiers in Immunology
Celiac Disease Research and Management
article

Acute gluten-induced inflammatory response highlights CCL20 as a potential biomarker for celiac disease

Sara Gómez-Aguililla, Beatriz Arau, Carolina Sousa, Concepción Núñez, Natalia López-Palacios, Mar Pujals, Carla Senosiain, Jorge Infante-Menéndez, Sergio Farrais, Ángela Ruiz-Carnicer, Nuria González-López, Fernando Fernández-Bañares
article en

Abstract

Gluten reintroduction triggers alterations in the inflammation-related protein profile of patients with CD. CCL20 emerges as a promising diagnostic candidate, its increase in plasma or serum, with low dependence on symptom presentation, may complement existing diagnostic approaches.

Frontiers in ImmunologyVol. 16
Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (ES), Unidad de Investigación en cuidados y servicios de salud (Investén-isciii) (ES), Hospital Universitario Fundación Jiménez Díaz (ES), Mútua Terrassa (ES), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (ES), Hospital Universitario Ramón y Cajal (ES), Universidad Autónoma de Madrid (ES), Universidad de Sevilla (ES)
Instituto de Salud Carlos III, European Regional Development Fund
Good health and well-being
Openalex Percentile: Top 90%
Celiac Disease Research and Management
DOIOpen Access PDFOpenAlex
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Acute gluten-induced inflammatory response highlights CCL20 as a potential biomarker for celiac disease — Sara Gómez-Aguililla, Beatriz Arau, et al. · Frontiers in Immunology (2026) | TGRS Research Map | TGRS