Systemic complement factors in aging, Alzheimer’s disease and other dementias: a longitudinal study over 10 years
The results of this study indicate an AD-specific peripheral complement signature associated with disease development, highlighting complement factors as critical immune mediators that link aging and AD. This signature implicates complement factors as promising systemic markers for early detection and potential therapeutic targeting in preclinical AD.
Authors
- Ziye Ren (ORCID: https://orcid.org/0009-0007-4572-0377)
- F. Li (ORCID: https://orcid.org/0000-0001-7574-1100)
- Longfei Jia
- Yuyun Xu (ORCID: https://orcid.org/0000-0003-2818-852X)
- Chengyu An (ORCID: https://orcid.org/0000-0003-0417-0376)
- Yana Pang
- Shuiyue Quan
- Xiaofeng Fu
- Yan Li
- Qi WANG
- Shuya Nie
- Wei Wang
- Lu Lu
- Weiyun Zhang
- QianQian Wang
- Jiaqi Li
- Changbiao Chu
- Huimin Cai
- Yumei Geng
- Qing Tian
Institutions
- Capital Medical University (CN)
Publication Details
- Journal
- Molecular Neurodegeneration
- Published
- 2026-01-12
- DOI
- https://doi.org/10.1186/s13024-026-00927-3
- Primary Topic
- Complement system in diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00