Association of genetically instrumented HMGCR inhibition with the therapeutic role of prostate cancer: a Mendelian randomization study and supporting in vitro experiments

HMGCR inhibition reduces the risk of PCa, and this protective effect is independent of its lipid-lowering action. Our findings provide strong genetic support for initiating RCTs to investigate the therapeutic potential of statins for partial PCa patients.

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Journal
Frontiers in Pharmacology
Published
2026-01-12
DOI
https://doi.org/10.3389/fphar.2025.1701869
Primary Topic
Cancer, Lipids, and Metabolism
Type
article
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article

Association of genetically instrumented HMGCR inhibition with the therapeutic role of prostate cancer: a Mendelian randomization study and supporting in vitro experiments

Jingjun Mu, Xiaojie Hao
Frontiers in Pharmacology
Cancer, Lipids, and Metabolism
article

Association of genetically instrumented HMGCR inhibition with the therapeutic role of prostate cancer: a Mendelian randomization study and supporting in vitro experiments

Jingjun Mu, Xiaojie Hao
article en

Abstract

HMGCR inhibition reduces the risk of PCa, and this protective effect is independent of its lipid-lowering action. Our findings provide strong genetic support for initiating RCTs to investigate the therapeutic potential of statins for partial PCa patients.

Frontiers in PharmacologyVol. 16
Shanxi Provincial Cancer Hospital (CN)
Good health and well-being
Openalex Percentile: Top 90%
Cancer, Lipids, and Metabolism
DOIOpen Access PDFOpenAlex
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Association of genetically instrumented HMGCR inhibition with the therapeutic role of prostate cancer: a Mendelian randomization study and supporting in vitro experiments — Jingjun Mu, Xiaojie Hao · Frontiers in Pharmacology (2026) | TGRS Research Map | TGRS