IL17-deficient NOD mice are protected from autoimmune diabetes due to decreased antigen presentation and T cell activation
Together, our data suggest a novel role for IL-17 in modulating epithelial cell function and antigen presentation within the intestinal tissue, resulting in reduced autoantigen-specific T cell responses and enhanced protection from autoimmune diabetes. Better understanding of how targeted IL-17 blockade could be administered to the intestine may help better prevent the development of Type 1 diabetes.
Authors
- Jian Peng (ORCID: https://orcid.org/0000-0003-0332-0248)
- James A. Pearson (ORCID: https://orcid.org/0000-0002-2867-2269)
- Wei Lü (ORCID: https://orcid.org/0000-0002-3009-1025)
- Juan Huang (ORCID: https://orcid.org/0000-0002-3364-0341)
- Li Wen
- F. Susan Wong
Institutions
- Yale University (US)
- Institute of Infection and Immunity (CA)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-01-12
- DOI
- https://doi.org/10.3389/fimmu.2025.1728313
- Primary Topic
- Diabetes and associated disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health
- Medical Research Council