Incidence and severity of SARS-CoV-2 infection and vaccine BNT162 side effects in children and adolescents with Noonan Syndrome: a national multicentric study
Children and adolescents with Noonan Syndrome generally experience a mild course of COVID-19 and show no evidence of increased vaccine-related risk. Despite the small sample size and the rarity of severe events, these findings yield valuable insights for patients living with this rare disease.
Authors
- Thomas Zoller (ORCID: https://orcid.org/0000-0001-5429-6036)
- Małgorzata Waśniewska (ORCID: https://orcid.org/0000-0002-8299-2677)
- Domenico Corica (ORCID: https://orcid.org/0000-0002-3628-1612)
- Eleonora Orlandini
- Sarah Dal Ben (ORCID: https://orcid.org/0000-0001-5222-4012)
- Michele Dalla Piazza
- Maria Felicia Faienza (ORCID: https://orcid.org/0000-0002-1899-8337)
- Rossella Gaudino (ORCID: https://orcid.org/0000-0002-6292-0246)
- Silvia Longhi
- Giuseppa Patti (ORCID: https://orcid.org/0000-0002-6217-1919)
- Donatella Capalbo (ORCID: https://orcid.org/0000-0003-3312-8628)
- Gabriella Pozzobon (ORCID: https://orcid.org/0000-0002-2618-2506)
- Franco Franco Antoniazzi
- Francesca Bonomo
- Roberto Franceschi
- Claudia Giavoli
- Chiara Corezzola
Institutions
- University of Messina (IT)
- University of Verona (IT)
- Vita-Salute San Raffaele University (IT)
- University of Milan (IT)
- University of Trento (IT)
- Istituto Giannina Gaslini (IT)
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT)
- Ospedale di Bolzano (IT)
- Federico II University Hospital (IT)
- Azienda USL di Bologna (IT)
- Mother Hospital (IN)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele (IT)
- University of Bari Aldo Moro (IT)
- University of Naples Federico II (IT)
- University of Genoa (IT)
Publication Details
- Journal
- Frontiers in Pediatrics
- Published
- 2026-01-12
- DOI
- https://doi.org/10.3389/fped.2025.1658340
- Primary Topic
- Protein Tyrosine Phosphatases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Università degli Studi di Verona