Significance of LEF1, ROR2, Cyclin D1, and DNA Methylation Profiling in the Molecular Classification and Prognosis Prediction of Pediatric Medulloblastoma
Nuclear LEF1 (nLEF1) is at least as effective as β-catenin in identifying WNT-AG and may serve as a superior diagnostic marker. Cyclin D1 can be used as a complementary marker in WNT-AG detection. ROR2 negativity may indicate G3 tumors, though further studies are warranted to confirm its prognostic value.
Authors
- Fatih Bayraklı (ORCID: https://orcid.org/0000-0003-0668-5453)
- Beste M. Atasoy (ORCID: https://orcid.org/0000-0003-1320-9105)
- Şükrü Bozkurt (ORCID: https://orcid.org/0000-0003-1938-3489)
- Adnan DAĞÇINAR
- Nursah Eker
- Yaşar Bayri
- Mehmet Fatih Tekin
- Dilek Gül
Institutions
- Istinye University (TR)
- Marmara University (TR)
Publication Details
- Journal
- Balkan Medical Journal
- Published
- 2026-01-12
- DOI
- https://doi.org/10.4274/balkanmedj.galenos.2025.2025-10-51
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00