Unveiling the immunometabolic landscape of colorectal cancer through PANoptosis-related gene expression
CDKN2A-mediated PANoptosis signaling network drives CRC progression by reshaping the immune microenvironment and metabolic reprogramming. The CPAN-index provides a new tool for accurate risk stratification of CRC patients, and suggests potential therapeutic strategies targeting the immunometabolism-death interaction network.
Authors
- Wenhao Wang (ORCID: https://orcid.org/0000-0002-0971-4232)
- Yiru Yin
- Xiaoyu He
- Li Li
- Shunbin Ding
Institutions
- Shanxi Medical University (CN)
- Deyang Stomatological Hospital (CN)
- Second Hospital of Shanxi Medical University (CN)
- Taiyuan University of Technology (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-01-12
- DOI
- https://doi.org/10.3389/fimmu.2025.1615022
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00