Effective prompt design for large language models in clinical practice

LLMs offer efficiency gains while requiring careful implementation. Physicians must develop prompt engineering competency, combining structured frameworks, RAG grounding strategies, and persistent human oversight for safe clinical integration. Prompt engineering literacy represents an essential emerging clinical skill.

Authors

Steven FJ Callens

Institutions

Ghent University Hospital (BE)
Belgian Society of Medical Oncology (BE)

Publication Details

Journal: Acta Clinica Belgica
Published: 2026-01-12
DOI: https://doi.org/10.1080/17843286.2026.2613903
Primary Topic: Artificial Intelligence in Healthcare and Education
Type: article
Field-Weighted Citation Impact: 0.00

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article

Effective prompt design for large language models in clinical practice

Steven FJ Callens

Jan 12, 2026

Acta Clinica Belgica

Artificial Intelligence in Healthcare and Education

article

Effective prompt design for large language models in clinical practice

Steven FJ Callens

January 12, 2026article en

Abstract

Acta Clinica BelgicaVol. 81(2)

Ghent University Hospital (BE), Belgian Society of Medical Oncology (BE)

Quality Education

Openalex Percentile: Top 91%

Artificial Intelligence in Healthcare and Education

DOI Source OpenAlex

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Effective prompt design for large language models in clinical practice — Steven FJ Callens · Acta Clinica Belgica (2026) | TGRS Research Map | TGRS