The efficacy and safety of lower-dose aspirin for primary and secondary prevention of cardiovascular disease in the elderly: an interim analysis of a multicenter, prospective, observational study
Aspirin 50 mg/day was associated with lower hemorrhage and gastrointestinal adverse event risks, with similar cardiovascular benefits, compared with aspirin 100 mg/day, and may be preferred to balance efficacy and safety for older Chinese adults in primary and secondary CVD prevention.
Authors
- Xiting Wang (ORCID: https://orcid.org/0000-0001-6072-6792)
- Xiulian Yan
- Q Q Zhang
- X. Liu
- Xuefen Qian
- Huaizhong Zhang (ORCID: https://orcid.org/0000-0001-7867-9453)
- Qing Liu (ORCID: https://orcid.org/0000-0003-3173-9492)
- Zhangyong Xia (ORCID: https://orcid.org/0000-0002-1627-0684)
- Sainan Zhu
- Y. Sun
- Xibo Sun
- M. Liu
- Pida Hao (ORCID: https://orcid.org/0009-0007-9756-365X)
- Hongwei Li (ORCID: https://orcid.org/0000-0003-2801-4482)
- Bo Liu (ORCID: https://orcid.org/0009-0007-5362-4406)
- Jianchun Wang (ORCID: https://orcid.org/0000-0002-4742-5634)
- Ya Wang (ORCID: https://orcid.org/0000-0002-1207-2453)
- Xia (ORCID: https://orcid.org/0009-0007-7564-255X)
- Yingwu Liu (ORCID: https://orcid.org/0009-0001-0521-7044)
- Aiping Jin
- Zhenghua Zhang
- Xiaoping Chen
- Lili Liu
- Yuan Wu
- Hong Qi
- Wei Miao
- Yong Liu
- Tao Tian
- Peng Dou
- Jiuyu Yang
- Keshan Liang
- Huanyu Guo
- Hongliang Cong
- Jianwei He
- Longmei Zhao
- Yingxin Zhao
- Zhengxiang Zhang
- Yan Hou
- Jie Hu
- Nabuqi He
Institutions
- Jiangsu University (CN)
- Binzhou Medical University (CN)
- Shandong University of Aeronautics (CN)
- Capital Medical University (CN)
- Chifeng University (CN)
- Peking University (CN)
- Tianjin Third Central Hospital (CN)
- First People’s Hospital of Jingmen (CN)
- The Fourth People's Hospital of Zibo City (CN)
- People’s Hospital of Rizhao (CN)
- Linyi People's Hospital (CN)
- Xuzhou Cancer Hospital (CN)
- Jinan Central Hospital (CN)
- Jiangxi Provincial People's Hospital (CN)
- Second Affiliated Hospital of Inner Mongolia Medical University (CN)
- Tianjin People's Hospital (CN)
- Shandong Provincial Hospital (CN)
- Beijing Anzhen Hospital (CN)
- Linzi District People's Hospital (CN)
- Chifeng Municipal Hospital (CN)
- Linyi City Chinese Medicine Hospital (CN)
- Yidu Central Hospital of Weifang (CN)
- The First People’s Hospital of Lianyungang (CN)
- Wuhan Union Hospital (CN)
- Peking University First Hospital (CN)
- Second Affiliated Hospital of Xi'an Jiaotong University (CN)
- Yancheng Second People's Hospital (CN)
- Taiyuan Central Hospital (CN)
- Tianjin Fourth Hospital (CN)
- Central Hospital of Zibo (CN)
- Tianjin Chest Hospital (CN)
- Tang Hospital (CN)
- Liaocheng People's Hospital (CN)
- Shandong First Medical University (CN)
- Union Hospital (CN)
- Tianjin Medical University (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Frontiers in Cardiovascular Medicine
- Published
- 2026-01-12
- DOI
- https://doi.org/10.3389/fcvm.2025.1615074
- Primary Topic
- Antiplatelet Therapy and Cardiovascular Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Peking University First Hospital
- Peking University