Moving beyond the hospital: in-depth characterization of daily-life mobility in patients with atypical Parkinsonian disorders
This study evaluates mobility in patients with multiple system atrophy (MSA), progressive supranuclear palsy (PSP), and Parkinson's disease (PD) by integrating clinical assessments, instrumented gait analysis (IGA) in the hospital, and 1 week of physical activity monitoring (PAM) at home, using wearable sensors. Clinical scores provide a broad measure of disease severity but lack precision in quantifying gait impairments. IGA offers objective gait metrics under standardized conditions, identifying deficits in stride dynamics and postural control. However, these controlled assessments do not reflect real-world mobility. PAM addresses this gap by continuously tracking movement patterns and physical activity during daily-life, offering insights into how patients walk beyond clinical settings. The combination of IGA and PAM provides a more comprehensive understanding of mobility limitations, particularly in MSA and PSP, where gait and balance impairments differ from PD. This dual approach enhances patient assessment, supports personalized disease management, and improves clinical decision-making. Trial registration: ClinicalTrials.gov, NCT04608604, date of registration: 19/10/2020, first patient enrollment: 01/02/2021.
Authors
- Bjoern M. Eskofier (ORCID: https://orcid.org/0000-0002-0417-0336)
- Victoria Sidoroff (ORCID: https://orcid.org/0000-0002-7434-6229)
- Gaëlle Prigent (ORCID: https://orcid.org/0000-0003-1618-4054)
- Mag Klaus Seppi
- Florian Krismer (ORCID: https://orcid.org/0000-0001-6427-6311)
- Jochen Klucken
- Hamid Moradi (ORCID: https://orcid.org/0009-0001-2715-8591)
- David Benninger
- Anisoara Ionescu (ORCID: https://orcid.org/0000-0002-2341-4383)
- Frank Jagusch
- Isabelle Teckenburg
- Marzieh Asalian
- Gregor Wenning
- Eva Tabea Schoenfeldt-Reichmann
- Cecilia Raccagni
- Stefano Sapienza
- MobilityAPP Study Group
- Kamiar Aminian
- Georg Goebel
- Nina Hergenroeder-Lenzner
- Jean-Pierre Ndayisaba
- Heiko Gassner
Institutions
- Innsbruck Medical University (AT)
- Centre Hospitalier de Luxembourg (LU)
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- University of Luxembourg (LU)
- Universität Innsbruck (AT)
- Paracelsus Medical University (AT)
- Centre Hospitalier Universitaire Vaudois (CH)
- Helmholtz Zentrum München (DE)
- Universitätsklinikum Erlangen (DE)
- Ospedale di Bolzano (IT)
- Fraunhofer Institute for Integrated Circuits (DE)
- Reha Rheinfelden (CH)
- École Polytechnique Fédérale de Lausanne (CH)
- University of Lausanne (CH)
Publication Details
- Journal
- npj Parkinson s Disease
- Published
- 2026-01-12
- DOI
- https://doi.org/10.1038/s41531-025-01242-2
- Citations
- 1
- Primary Topic
- Balance, Gait, and Falls Prevention
- Type
- article
- Field-Weighted Citation Impact
- 60.11
Funders
- Deutsche Forschungsgemeinschaft
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Fonds National de la Recherche Luxembourg
- Austrian Science Fund