Combination of GLP-1 receptor agonist and Akkermansia muciniphila Akk11 reduces adiposity and ameliorates MASLD in T2D mice
Our findings highlight a synergistic interaction between GLP-1RA and Akk11, likely mediated through microbiota remodeling and parallel improvements in lipid metabolism across intestinal, hepatic, and adipose compartments. This study supports the development of microbiota-guided strategies to enhance therapies for MASLD and other metabolic diseases.
Authors
- Gao Kaige
- Caifeng Jiang
- Runqi Wang (ORCID: https://orcid.org/0000-0003-0800-3954)
- Bin Guo
- Zixuan Dong
- Yu Feng
- Xiangpeng Liu
- Hong Sun
- Zhihao Jia
- Chi Zhang
- Zhengyu Zhou
- Yalin Wang
- Qian Chen
- Zaifei Yin
Institutions
- Soochow University (CN)
- Second Affiliated Hospital of Soochow University (CN)
- Probiotical (Italy) (IT)
- First Affiliated Hospital of Soochow University (CN)
- Xi’an Jiaotong-Liverpool University (CN)
Publication Details
- Journal
- Cell & Bioscience
- Published
- 2026-01-12
- DOI
- https://doi.org/10.1186/s13578-025-01525-4
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00