TRIM29 drives ulcerative colitis by disrupting lipid metabolism via lysosomal dysfunction: a multi-omics and experimental study
This study identifies TRIM29 as a master regulator that drives UC progression by disrupting lysosomal function and reprogramming lipid metabolism. Our work delineates the TRIM29-lysosome-lipid metabolism axis, providing a mechanistic rationale for targeting TRIM29 as a promising therapeutic strategy in UC.
Authors
- Xing-Zhou Guo
- Yafei Liu (ORCID: https://orcid.org/0000-0002-5356-6599)
- Bin Yu (ORCID: https://orcid.org/0000-0002-2612-1287)
- Haodong He (ORCID: https://orcid.org/0000-0002-3655-3905)
- Wei-Guo Dong
- Zong-Biao Tan
- Lu-Yun Zhang
Institutions
- Wuhan University (CN)
- Renmin Hospital of Wuhan University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-01-12
- DOI
- https://doi.org/10.3389/fimmu.2025.1728932
- Citations
- 1
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 24.43
Funders
- National Natural Science Foundation of China
- Wuhan University