The triglyceride-high-density lipoprotein-glucose-body index: a superior novel biomarker for diabetic kidney disease in type 2 diabetes

The TyHGB index exhibits a robust, independent, and non-linear association with DKD risk in T2DM patients and outperforms the established TyG index. As a readily accessible composite metric, it holds significant promise as a superior tool for early identification and risk stratification of DKD in clinical practice.

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Publication Details

Journal
Frontiers in Endocrinology
Published
2026-01-12
DOI
https://doi.org/10.3389/fendo.2025.1749826
Primary Topic
Chronic Kidney Disease and Diabetes
Type
article
Field-Weighted Citation Impact
0.00

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article

The triglyceride-high-density lipoprotein-glucose-body index: a superior novel biomarker for diabetic kidney disease in type 2 diabetes

Zhiling Deng, Jian Yang, Bingsong Xie, Hairong Zhou et al.
Frontiers in Endocrinology
Chronic Kidney Disease and Diabetes
article

The triglyceride-high-density lipoprotein-glucose-body index: a superior novel biomarker for diabetic kidney disease in type 2 diabetes

Zhiling Deng, Jian Yang, Bingsong Xie, Hairong Zhou, Zhifu Zhang
article en

Abstract

The TyHGB index exhibits a robust, independent, and non-linear association with DKD risk in T2DM patients and outperforms the established TyG index. As a readily accessible composite metric, it holds significant promise as a superior tool for early identification and risk stratification of DKD in clinical practice.

Frontiers in EndocrinologyVol. 16
Sun Yat-sen University (CN), Longgang Central Hospital (CN), ShenZhen People’s Hospital (CN), Shenzhen Bao'an District People's Hospital (CN), Eighth Affiliated Hospital of Sun Yat-sen University
Sun Yat-sen University
Peace, Justice and strong institutions, Reduced inequalities
Openalex Percentile: Top 92%
Chronic Kidney Disease and Diabetes
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