Prognostic value of the controlling nutritional status (CONUT) and the Prognostic Nutritional Index (PNI) scores in mycosis fungoides

Aims: Mycosis fungoides (MF) is the most prevalent cutaneous T-cell lymphoma, exhibiting an indolent but potentially progressive course. Although the tumor-node-metastasis-blood (TNMB) system is the standard prognostic tool, survival outcomes vary among patients with the same stage, underscoring the need for complementary biomarkers. The Controlling Nutritional Status (CONUT) score and the Prognostic Nutritional Index (PNI) are composite indicators reflecting systemic nutritional and immune status. Their prognostic value has been established in hematologic malignancies, but their role in MF remains unclear. To evaluate the prognostic significance of CONUT and PNI scores in MF and to examine their associations with disease stage, inflammatory markers, and clinical progression. Methods: This retrospective study included 130 patients with histologically confirmed MF. Demographic, clinical, and laboratory parameters were collected at baseline. CONUT and PNI were calculated using serum albumin, total cholesterol, and lymphocyte count. Patients were classified into early (IA-IIA) and advanced (≥IIB) stages per ISCL/EORTC criteria. Comparative analyses, Spearman correlations, ROC curve analyses, and multivariate logistic regressions were performed to determine predictive factors for advanced disease (p