Lipid balance and chemoresistance in cancer cells

A shift in the balance between two lipids - cholesterol and sphingomyelin - makes hybrid epithelial-mesenchymal cancer cells less responsive to certain chemotherapy drugs.

Authors

Kaori Kanemaru (ORCID: https://orcid.org/0000-0002-9352-0229)
Yusuke Nakamura (ORCID: https://orcid.org/0009-0004-6320-7030)

Institutions

Tokyo University of Science (JP)

Publication Details

Journal: eLife
Published: 2026-01-12
DOI: https://doi.org/10.7554/elife.110231
Primary Topic: Cancer, Lipids, and Metabolism
Type: article
Field-Weighted Citation Impact: 0.00

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article

Lipid balance and chemoresistance in cancer cells

Kaori Kanemaru, Yusuke Nakamura

Jan 12, 2026

eLife

Cancer, Lipids, and Metabolism

article

Lipid balance and chemoresistance in cancer cells

Kaori Kanemaru, Yusuke Nakamura

January 12, 2026article en

Abstract

A shift in the balance between two lipids - cholesterol and sphingomyelin - makes hybrid epithelial-mesenchymal cancer cells less responsive to certain chemotherapy drugs.

eLifeVol. 15

Tokyo University of Science (JP)

Good health and well-being

Openalex Percentile: Top 90%

Cancer, Lipids, and Metabolism

DOI Open Access PDF OpenAlex

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Lipid balance and chemoresistance in cancer cells — Kaori Kanemaru, Yusuke Nakamura · eLife (2026) | TGRS Research Map | TGRS