Multi-omics integration identifies NK cell dysregulation and a five-gene diagnostic signature in major depressive disorder
Our study establishes NK cell dysfunction as a core pathophysiological mechanism in MDD, characterized by cellular expansion and metabolic alterations. The identified key genes serve as robust diagnostic biomarkers and therapeutic targets. Elucidation of their regulatory networks provides critical insights for precision psychiatry interventions.
Authors
- X. Steven Chen (ORCID: https://orcid.org/0009-0007-1225-7945)
- Ye Kuang (ORCID: https://orcid.org/0000-0003-4946-3447)
- Jin Li (ORCID: https://orcid.org/0000-0002-6131-456X)
- Li Feng (ORCID: https://orcid.org/0000-0003-4123-0892)
- Yuanyuan Zhou (ORCID: https://orcid.org/0000-0002-8993-8753)
- C B Peng
- Sulian Chen
- Jia Wang
- Shengjie Nie
- Jinrong Tian
- Yong Yuan
- Yong Ji
Institutions
- Kunming Medical University (CN)
- Yan'an Hospital Affiliated To Kunming Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-01-12
- DOI
- https://doi.org/10.3389/fimmu.2025.1700629
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 0.00